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KMID : 0942820020010020113
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Journal of Korean Brain Tumor Society
2002 Volume.1 No. 2 p.113 ~ p.119
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Long-term Outcome of the Anaplastic Oligodendroglioma
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Lee June-Ho
Kim Chae-Yong
Hwang Sung-Kyun
Paek Sun-Ha
Kim Dong-Gyu
Jung Hee-Won
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Abstract
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Objective: Aggressive oligodendroglioma(ODG) is reported to be more sensitive to chemotherapy than other glial
tumors. Authors retrospectively analyzed the clinical outcome of anaplastic ODG after treatment with cytoreductive
surgery and then adjuvant chemotherapy following radiotherapy.
Methods: The clinical records of 25 anaplastic ODG patients, registered between 1991 and 1998 and then followed-up more than two years after completion of each treatment, were reviewed. These patients were subdivided by the degree of resection and the treatment modality；operation+radiotherapy group versus operation+radiotherapy+adjuvant chemotherapy( PCV regimen) group. Treatment outcomes were evaluated by the presence of recurrence in follow-up magnetic resonance image(MRI) and the recurrence-free survival curves were obtained for each group by using Kaplan-Meier method. The mean follow-up period for anaplastic ODG was 57.7 months.
Results: There were only five cases of recurrence among the14 patients(36%) with anaplastic ODG treated with operation+ radiotherapy alone compared to two of 10 patients treated with adjuvant chemotherapy after peration radiotherapy. The recurrence-free survival period for operation+radiotherapy groups was 82.8 months compared to 82.5 months for adjuvant chemotherapy groups. The recurrence-free survival for the patients with more than near totally resected anaplastic ODG showed twice as long as those less than subtotally resected group
Conclusion: Contrary to previous reports on anaplastic ODG as a chemosensitive tumor, recurrence rate and recurrencefree survival period for the anaplastic ODG patients treated with adjuvant chemotherapy was not significantly different from those treated with operation+radiotherapy alone. However, the degree of resection affected the recurrence-free survival in anaplastic ODG irrelevant to the treatment modality.
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KEYWORD
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Adjuvant chemotherapy, Anaplastic oligodendroglioma, Radiotherapy, Long-term outcome
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